Online HPLC Dissolution

For automated on-line dissolution sampling and analysis one combination leads the industry: The Waters® Alliance™ HPLC Dissolution system with the Hanson SR8-Plus™ dissolution baths.

The Alliance Dissolution System directly transfers samples from single or dual dissolution baths (6 or 8 vessel) to vials housed inside the Waters 2690D Separations Module.

Integral to the 2690D Separations Module is a dissolution dispenser with 6 or 8-vessel sampling capability that accepts sample aliquots from most dissolution baths. The 2690D Separations Module, together with the Empower software, runs dissolution methods, downloading sampling times and sample aliquot volumes to the Waters Transfer Module. Waters Transfer Module is driven by a stepper motor, not pneumatics, enabling you to work with surfactant-containing media. Waters Transfer Module uses a microprocessor-controlled array of syringe pumps to take dissolution samples from 6 or 8 vessels simultaneously and transfer the samples into vials housed in the 2690D Separations Module. Once the samples are in the vials, the 2690D Separations Module processes the samples until it is time to accept more dissolution samples.

When paired with a Hanson SR8-Plus Dissolution Bath, the 2690D Separations Module downloads dissolution methods (shaft speed, bath temperature and other parameters) directly to the SR8-Plus Bath. The Alliance Dissolution System can control and monitor the function of up to two Hanson SR8-Plus dissolution baths.